Mercedes-Benz E350 — All Years
| Year | Engine | Fuel | MPG (UK) | NHTSA |
|---|---|---|---|---|
| 2024 | 2L 4-cyl | Premium Gasoline | 32 | — |
| 2023 | 2L 4-cyl | Premium Gasoline | 31 | — |
| 2022 | 2L 4-cyl | Premium Gasoline | 31 | — |
| 2021 | 2L 4-cyl | Premium Gasoline | 30 | — |
| 2020 | 2L 4-cyl | Premium Gasoline | 31 | — |
| 2016 | 3.5L 6-cyl | Premium Gasoline | 28 | — |
| 2015 | 3.5L 6-cyl | Premium Gasoline | 28 | — |
| 2014 | 3.5L 6-cyl | Premium Gasoline | 28 | — |
| 2013 | 3.5L 6-cyl | Premium Gasoline | 26 | — |
| 2012 | 3.5L 6-cyl | Premium Gasoline | 26 | — |
| 2011 | 3.5L 6-cyl | Premium Gasoline | 23 | — |
| 2010 | 3.5L 6-cyl | Premium Gasoline | 25 | — |
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