2010 Mercedes-Benz E350 — Full Specifications
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The 2010 Mercedes-Benz E350 is a saloon/sedan powered by a 3.5L 6-cyl premium gasoline engine. Its most fuel-efficient configuration returns around 25 mpg (UK) / 21 mpg (US EPA) combined, with 23–25 mpg (UK) across all configurations. Owners often keep a Mercedes-Benz E350 workshop manual to hand for servicing and repairs.
Related 2010 listings: Mercedes-Benz E350 Coupe.
Full Specifications
| Engine | 3.5L 6-cyl |
|---|---|
| Transmission | Automatic 7-spd |
| Fuel Type | Premium Gasoline |
| Powertrain | Conventional |
| Drive | Rear-Wheel Drive |
| Body Style | Saloon/Sedan |
| Passenger Volume (EPA) | 97 cu ft (2,747 L) |
| Luggage Volume (EPA) | 14 cu ft (396 L) |
| Fuel Economy (UK) | 25 combined / 22 urban / 31 extra-urban mpg |
| Fuel Economy (US EPA) | 21 combined / 18 city / 26 highway mpg |
| CO₂ Emissions | 263 g/km |
| EPA Est. Annual Fuel Cost | $3,900 (15,000 mi/yr, US prices) |
Engine & Transmission Options
EPA lists 2 configurations for the 2010 Mercedes-Benz E350, all with the 3.5L 6-cyl engine. Combined fuel economy ranges from 19 to 21 mpg (US), or 23 to 25 mpg (UK), depending on engine, transmission and drive. The headline figures at the top of this page describe the most fuel-efficient configuration.
| Engine | Transmission | Drive | MPG (UK) | MPG (US) | CO₂ g/km | Fuel cost / yr |
|---|---|---|---|---|---|---|
| 3.5L 6-cyl | Automatic 7-spd | 4-Wheel Drive | 23 | 19 (17/24) | 291 | $4,350 |
| 3.5L 6-cyl | Automatic 7-spd | Rear-Wheel Drive | 25 | 21 (18/26) | 263 | $3,900 |
MPG (US) shows combined, with city/highway in brackets. Highlighted row = the configuration used for the headline figures. Source: US EPA fueleconomy.gov.
EPA measures interior passenger volume at 97 cubic feet (about 2,747 litres) and luggage volume at 14 cubic feet (about 396 litres). These are US EPA interior-volume figures; they are measured differently from the boot capacity numbers UK manufacturers quote.
Owner Essentials for the 2010 Mercedes-Benz E350
Running Costs: 2010 Mercedes-Benz E350
Covering around 8,000 miles a year in a 2010 Mercedes-Benz E350 at 25 mpg combined, expect roughly 1,455 litres of fuel annually — multiply by your local price per litre for a cost estimate. For US owners, the EPA estimates about $3,900 a year in fuel for the most efficient configuration (15,000 miles, national average prices). Work out exact fuel costs with the fuel cost calculator on 247Calculators.
Convert between MPG and L/100km with the unit converters on 247QuickTools. Not sure what tyre size fits? 247TyreCheck explains tyre sizing.
Only need this car occasionally? See our buy vs rent comparison.
2010 Mercedes-Benz E350 Safety Ratings (NHTSA)
No NHTSA crash-test rating is on record for this model year. The NHTSA rates only a subset of vehicles each year; you can browse every rated vehicle on our NHTSA Safety Ratings hub.
Recalls & Owner Complaints (NHTSA)
NHTSA lists no safety recall campaigns for the 2010 Mercedes-Benz E350 as of 6 October 2026. Recalls can be issued years after a model is sold, so it is still worth checking your own VIN.
Owners have filed 258 complaints with NHTSA about the 2010 Mercedes-Benz E350. The most-reported areas are Air bags (100), Suspension (44), Unspecified (23). Complaints include 9 reported crashes, 6 reported injuries. That is well above the median of 41 complaints across the 14 Mercedes-Benz E350 model years in our data.
Used-buyer checklist for the 2010 Mercedes-Benz E350
Based on where NHTSA recalls and owner complaints cluster for this model year, these are the areas worth checking before you buy:
- Air bags (100 owner complaints) — Confirm any air bag inflator or module recalls were completed — enter the VIN at nhtsa.gov/recalls.
- Suspension (44 owner complaints) — Listen for knocks over bumps and check tyre wear for signs of alignment problems.
- Fuel system (22 owner complaints) — Ask whether any fuel-pump or fuel-system recalls were completed, and watch for hard starting or stalling.
Source: US NHTSA recall and consumer-complaint databases, retrieved 6 October 2026. Complaints are unverified owner reports, not confirmed defects. Check any vehicle by VIN at nhtsa.gov/recalls, and see our guide to checking a used car for recalls.
How It Compares
At 25 mpg (UK) combined it sits close to the 26 mpg average for Mercedes-Benz models in our database.
Of the 14 Mercedes-Benz E350 model years we cover, the 2010 ranks 13th for combined fuel economy on its best configuration (25 mpg UK combined, against a high of 34 mpg). See every Mercedes-Benz E350 year side by side.
Last updated: · Data: US EPA (fueleconomy.gov) and NHTSA safety ratings 18 July 2026; NHTSA recalls and complaints 6 October 2026; Wikidata & curated EU catalogue 18 July 2026; European generation and engine data from Wikipedia 7 October 2026
Vehicle data sourced from manufacturer specifications. Always verify with your vehicle handbook or a qualified mechanic. This is a reference tool, not professional advice.
Recommended Accessories for the 2010 Mercedes-Benz E350
Frequently Asked Questions
What engine does the 2010 Mercedes-Benz E350 have?
It's fitted with a 3.5L 6-cyl premium gasoline engine, paired with a automatic 7-spd transmission.
What is the fuel economy of the 2010 Mercedes-Benz E350?
The most efficient configuration returns around 25 mpg (UK) combined, or 21 mpg on the US EPA cycle. Across all configurations the UK combined figure runs from 23 to 25 mpg.
How much does the 2010 Mercedes-Benz E350 cost to fuel per year?
The US EPA estimates about $3,900 a year in fuel for the most efficient configuration, based on 15,000 miles of mixed driving and national average fuel prices. Your own cost will depend on mileage and local prices.
Does the 2010 Mercedes-Benz E350 have any recalls?
NHTSA lists no safety recall campaigns for the 2010 Mercedes-Benz E350 as of 6 October 2026. Recalls can be issued years after a model is sold, so it is still worth checking your own VIN.
What are the most common problems reported for the 2010 Mercedes-Benz E350?
Among the 258 owner complaints filed with NHTSA, the most-reported areas are Air bags (100 complaints), Suspension (44 complaints), Unspecified (23 complaints). Complaints are unverified owner reports, not confirmed defects, and raw counts rise with how many cars were sold.
How much interior and luggage space does the 2010 Mercedes-Benz E350 have?
EPA measures interior passenger volume at 97 cubic feet (about 2,747 litres) and luggage volume at 14 cubic feet (about 396 litres). These are US EPA interior-volume figures, which are measured differently from the UK boot-capacity numbers manufacturers quote.