2021 Mercedes-Benz E350 — Full Specifications
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The 2021 Mercedes-Benz E350 is a saloon/sedan powered by a 2L 4-cyl turbo premium gasoline engine. It returns around 30 mpg (UK) / 25 mpg (US EPA) combined. Owners often keep a Mercedes-Benz E350 workshop manual to hand for servicing and repairs.
Compared with the 2020 Mercedes-Benz E350: Fuel economy is essentially unchanged at around 30 mpg (UK) combined. The engine line-up listed by EPA is unchanged. It carries the same 5★ overall NHTSA rating.
Full Specifications
| Engine | 2L 4-cyl turbo |
|---|---|
| Transmission | Automatic 9-spd |
| Fuel Type | Premium Gasoline |
| Powertrain | Conventional |
| Drive | Rear-Wheel Drive |
| Body Style | Saloon/Sedan |
| Passenger Volume (EPA) | 98 cu ft (2,775 L) |
| Luggage Volume (EPA) | 13 cu ft (368 L) |
| Fuel Economy (UK) | 30 combined / 26 urban / 37 extra-urban mpg |
| Fuel Economy (US EPA) | 25 combined / 22 city / 31 highway mpg |
| CO₂ Emissions | 217 g/km |
| EPA Greenhouse Gas Score | 5 / 10 (10 = lowest emissions) |
| EPA Est. Annual Fuel Cost | $3,300 (15,000 mi/yr, US prices) |
Engine & Transmission Options
EPA lists 2 configurations for the 2021 Mercedes-Benz E350, all with the 2L 4-cyl turbo engine. The headline figures at the top of this page describe the most fuel-efficient configuration.
| Engine | Transmission | Drive | MPG (UK) | MPG (US) | CO₂ g/km | Fuel cost / yr |
|---|---|---|---|---|---|---|
| 2L 4-cyl turbo | Automatic 9-spd | 4-Wheel Drive | 30 | 25 (22/30) | 221 | $3,300 |
| 2L 4-cyl turbo | Automatic 9-spd | Rear-Wheel Drive | 30 | 25 (22/31) | 217 | $3,300 |
MPG (US) shows combined, with city/highway in brackets. Highlighted row = the configuration used for the headline figures. Source: US EPA fueleconomy.gov.
EPA measures interior passenger volume at 98 cubic feet (about 2,775 litres) and luggage volume at 13 cubic feet (about 368 litres). These are US EPA interior-volume figures; they are measured differently from the boot capacity numbers UK manufacturers quote.
Owner Essentials for the 2021 Mercedes-Benz E350
Running Costs: 2021 Mercedes-Benz E350
Covering around 8,000 miles a year in a 2021 Mercedes-Benz E350 at 30 mpg combined, expect roughly 1,212 litres of fuel annually — multiply by your local price per litre for a cost estimate. For US owners, the EPA estimates about $3,300 a year in fuel for the most efficient configuration (15,000 miles, national average prices). Work out exact fuel costs with the fuel cost calculator on 247Calculators.
Convert between MPG and L/100km with the unit converters on 247QuickTools. Not sure what tyre size fits? 247TyreCheck explains tyre sizing.
Only need this car occasionally? See our buy vs rent comparison.
2021 Mercedes-Benz E350 Safety Ratings (NHTSA)
Recalls & Owner Complaints (NHTSA)
NHTSA lists no safety recall campaigns for the 2021 Mercedes-Benz E350 as of 6 October 2026. Recalls can be issued years after a model is sold, so it is still worth checking your own VIN.
Owners have filed 20 complaints with NHTSA about the 2021 Mercedes-Benz E350. The most-reported areas are Electrical system (7), Engine (6), Power train (3). Complaints include 1 reported fire. That is well below the median of 41 complaints across the 14 Mercedes-Benz E350 model years in our data.
Used-buyer checklist for the 2021 Mercedes-Benz E350
Based on where NHTSA recalls and owner complaints cluster for this model year, these are the areas worth checking before you buy:
- Electrical system (7 owner complaints) — Test every switch, window, light and warning lamp on a test drive, and ask about battery or alternator replacements.
- Engine (6 owner complaints) — Listen for unusual noise on a cold start, check for warning lights and ask for the service records.
- Transmission & drivetrain (3 owner complaints) — On the test drive, watch for hesitation, jerking or slipping between gears and ask for transmission service history.
Source: US NHTSA recall and consumer-complaint databases, retrieved 6 October 2026. Complaints are unverified owner reports, not confirmed defects. Check any vehicle by VIN at nhtsa.gov/recalls, and see our guide to checking a used car for recalls.
How It Compares
Mercedes-Benz models in our database average about 26 mpg (UK) combined on their most efficient configuration; the 2021 Mercedes-Benz E350's 30 mpg is 4 mpg above that make average. Its 217 g/km CO₂ figure is 51 g/km lower than the 268 g/km Mercedes-Benz average.
Of the 14 Mercedes-Benz E350 model years we cover, the 2021 ranks 7th for combined fuel economy on its best configuration (30 mpg UK combined, against a high of 34 mpg). See every Mercedes-Benz E350 year side by side.
Last updated: · Data: US EPA (fueleconomy.gov) and NHTSA safety ratings 18 July 2026; NHTSA recalls and complaints 6 October 2026; Wikidata & curated EU catalogue 18 July 2026; European generation and engine data from Wikipedia 7 October 2026
Vehicle data sourced from manufacturer specifications. Always verify with your vehicle handbook or a qualified mechanic. This is a reference tool, not professional advice.
Recommended Accessories for the 2021 Mercedes-Benz E350
Frequently Asked Questions
What engine does the 2021 Mercedes-Benz E350 have?
It's fitted with a 2L 4-cyl turbo premium gasoline engine, paired with a automatic 9-spd transmission.
What is the fuel economy of the 2021 Mercedes-Benz E350?
The most efficient configuration returns around 30 mpg (UK) combined, or 25 mpg on the US EPA cycle.
How much does the 2021 Mercedes-Benz E350 cost to fuel per year?
The US EPA estimates about $3,300 a year in fuel for the most efficient configuration, based on 15,000 miles of mixed driving and national average fuel prices. Your own cost will depend on mileage and local prices.
Does the 2021 Mercedes-Benz E350 have a good safety rating?
It holds an overall NHTSA rating of 5 stars, with 5 stars for frontal crash protection.
Does the 2021 Mercedes-Benz E350 have any recalls?
NHTSA lists no safety recall campaigns for the 2021 Mercedes-Benz E350 as of 6 October 2026. Recalls can be issued years after a model is sold, so it is still worth checking your own VIN.
What are the most common problems reported for the 2021 Mercedes-Benz E350?
Among the 20 owner complaints filed with NHTSA, the most-reported areas are Electrical system (7 complaints), Engine (6 complaints), Power train (3 complaints). Complaints are unverified owner reports, not confirmed defects, and raw counts rise with how many cars were sold.
How much interior and luggage space does the 2021 Mercedes-Benz E350 have?
EPA measures interior passenger volume at 98 cubic feet (about 2,775 litres) and luggage volume at 13 cubic feet (about 368 litres). These are US EPA interior-volume figures, which are measured differently from the UK boot-capacity numbers manufacturers quote.