2025 Mercedes-Benz E350 — Full Specifications
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The 2025 Mercedes-Benz E350 is a saloon/sedan powered by a 2L 4-cyl turbo premium gasoline engine. Its most fuel-efficient configuration returns around 34 mpg (UK) / 28 mpg (US EPA) combined, with 32–34 mpg (UK) across all configurations. Owners often keep a Mercedes-Benz E350 workshop manual to hand for servicing and repairs.
Compared with the 2024 Mercedes-Benz E350: Fuel economy improves from 32 to 34 mpg (UK) combined on the most efficient configuration. The engine line-up listed by EPA is unchanged.
Full Specifications
| Engine | 2L 4-cyl turbo |
|---|---|
| Transmission | Automatic 9-spd |
| Fuel Type | Premium Gasoline |
| Powertrain | Hybrid |
| Drive | Rear-Wheel Drive |
| Body Style | Saloon/Sedan |
| Passenger Volume (EPA) | 100 cu ft (2,832 L) |
| Luggage Volume (EPA) | 13 cu ft (368 L) |
| Fuel Economy (UK) | 34 combined / 30 urban / 40 extra-urban mpg |
| Fuel Economy (US EPA) | 28 combined / 25 city / 33 highway mpg |
| CO₂ Emissions | 196 g/km |
| EPA Greenhouse Gas Score | 6 / 10 (10 = lowest emissions) |
| EPA Est. Annual Fuel Cost | $2,950 (15,000 mi/yr, US prices) |
Engine & Transmission Options
EPA lists 2 configurations for the 2025 Mercedes-Benz E350, all with the 2L 4-cyl turbo engine. Combined fuel economy ranges from 27 to 28 mpg (US), or 32 to 34 mpg (UK), depending on engine, transmission and drive. The headline figures at the top of this page describe the most fuel-efficient configuration.
| Engine | Transmission | Drive | MPG (UK) | MPG (US) | CO₂ g/km | Fuel cost / yr |
|---|---|---|---|---|---|---|
| 2L 4-cyl turbo (Hybrid) | Automatic 9-spd | All-Wheel Drive | 32 | 27 (24/33) | 203 | $3,050 |
| 2L 4-cyl turbo (Hybrid) | Automatic 9-spd | Rear-Wheel Drive | 34 | 28 (25/33) | 196 | $2,950 |
MPG (US) shows combined, with city/highway in brackets. Highlighted row = the configuration used for the headline figures. Source: US EPA fueleconomy.gov.
EPA measures interior passenger volume at 100 cubic feet (about 2,832 litres) and luggage volume at 13 cubic feet (about 368 litres). These are US EPA interior-volume figures; they are measured differently from the boot capacity numbers UK manufacturers quote.
Owner Essentials for the 2025 Mercedes-Benz E350
Running Costs: 2025 Mercedes-Benz E350
Covering around 8,000 miles a year in a 2025 Mercedes-Benz E350 at 34 mpg combined, expect roughly 1,070 litres of fuel annually — multiply by your local price per litre for a cost estimate. For US owners, the EPA estimates about $2,950 a year in fuel for the most efficient configuration (15,000 miles, national average prices). Work out exact fuel costs with the fuel cost calculator on 247Calculators.
Convert between MPG and L/100km with the unit converters on 247QuickTools. Not sure what tyre size fits? 247TyreCheck explains tyre sizing.
Only need this car occasionally? See our buy vs rent comparison.
2025 Mercedes-Benz E350 Safety Ratings (NHTSA)
No NHTSA crash-test rating is on record for this model year. The NHTSA rates only a subset of vehicles each year; you can browse every rated vehicle on our NHTSA Safety Ratings hub.
Recalls & Owner Complaints (NHTSA)
NHTSA lists 2 safety recall campaigns that include the 2025 Mercedes-Benz E350 (as of 6 October 2026). Most affected areas: Electrical system (1), Power train (1). 1 campaign carried a “do not drive” or “park outside” advisory. A campaign often covers several model years or models, so check your own VIN to see whether your car is affected.
- Electrical system — campaign 26V281000, reported 1 May 2026. Risk: An instrument panel display that fails to show critical safety information, such as the speedometer and warning lights, increases the risk of a crash.
- Power train — campaign 24V941000, reported 18 December 2024. Risk: Rear axle carrier failure can cause a sudden loss of vehicle handling and control, increasing the risk of a crash.
Owners have filed 5 complaints with NHTSA about the 2025 Mercedes-Benz E350. The most-reported areas are Electrical system (3), Unspecified (2), Visibility/wiper (1). That is well below the median of 41 complaints across the 14 Mercedes-Benz E350 model years in our data.
Used-buyer checklist for the 2025 Mercedes-Benz E350
Based on where NHTSA recalls and owner complaints cluster for this model year, these are the areas worth checking before you buy:
- Electrical system (1 recall campaign · 3 owner complaints) — Test every switch, window, light and warning lamp on a test drive, and ask about battery or alternator replacements.
- Transmission & drivetrain (1 recall campaign) — On the test drive, watch for hesitation, jerking or slipping between gears and ask for transmission service history.
- Visibility (1 owner complaint) — Check wipers, washers and demisters work properly.
- Engine (1 owner complaint) — Listen for unusual noise on a cold start, check for warning lights and ask for the service records.
Source: US NHTSA recall and consumer-complaint databases, retrieved 6 October 2026. Complaints are unverified owner reports, not confirmed defects. Check any vehicle by VIN at nhtsa.gov/recalls, and see our guide to checking a used car for recalls.
How It Compares
Mercedes-Benz models in our database average about 26 mpg (UK) combined on their most efficient configuration; the 2025 Mercedes-Benz E350's 34 mpg is 8 mpg above that make average. Its 196 g/km CO₂ figure is 72 g/km lower than the 268 g/km Mercedes-Benz average.
Of the 14 Mercedes-Benz E350 model years we cover, the 2025 is the most economical on its best configuration (34 mpg UK combined). See every Mercedes-Benz E350 year side by side.
Last updated: · Data: US EPA (fueleconomy.gov) and NHTSA safety ratings 18 July 2026; NHTSA recalls and complaints 6 October 2026; Wikidata & curated EU catalogue 18 July 2026; European generation and engine data from Wikipedia 7 October 2026
Vehicle data sourced from manufacturer specifications. Always verify with your vehicle handbook or a qualified mechanic. This is a reference tool, not professional advice.
Recommended Accessories for the 2025 Mercedes-Benz E350
Frequently Asked Questions
What engine does the 2025 Mercedes-Benz E350 have?
It's fitted with a 2L 4-cyl turbo premium gasoline engine, paired with a automatic 9-spd transmission.
What is the fuel economy of the 2025 Mercedes-Benz E350?
The most efficient configuration returns around 34 mpg (UK) combined, or 28 mpg on the US EPA cycle. Across all configurations the UK combined figure runs from 32 to 34 mpg.
How much does the 2025 Mercedes-Benz E350 cost to fuel per year?
The US EPA estimates about $2,950 a year in fuel for the most efficient configuration, based on 15,000 miles of mixed driving and national average fuel prices. Your own cost will depend on mileage and local prices.
Does the 2025 Mercedes-Benz E350 have any recalls?
NHTSA lists 2 safety recall campaigns that include the 2025 Mercedes-Benz E350 (as of 6 October 2026). Most affected areas: Electrical system (1), Power train (1). 1 campaign carried a “do not drive” or “park outside” advisory. A campaign often covers several model years or models, so check your own VIN to see whether your car is affected.
What are the most common problems reported for the 2025 Mercedes-Benz E350?
Among the 5 owner complaints filed with NHTSA, the most-reported areas are Electrical system (3 complaints), Unspecified (2 complaints), Visibility/wiper (1 complaint). Complaints are unverified owner reports, not confirmed defects, and raw counts rise with how many cars were sold.
How much interior and luggage space does the 2025 Mercedes-Benz E350 have?
EPA measures interior passenger volume at 100 cubic feet (about 2,832 litres) and luggage volume at 13 cubic feet (about 368 litres). These are US EPA interior-volume figures, which are measured differently from the UK boot-capacity numbers manufacturers quote.