Acura TLX vs Mercedes-Benz E350
This page compares the Acura TLX and the Mercedes-Benz E350 across the 8 model years both appear in our data (2015–2025). Both are classed as Saloon/Sedan on this site. Both average about 31 mpg (UK) on their most efficient configurations. NHTSA lists fewer recall campaigns per model year for the Mercedes-Benz E350 (0.2 against 4.6), though campaign counts depend on how long each model has been on sale and how many variants share a campaign.
Head-to-Head: 2015–2025
| Measure | Acura TLX | Mercedes-Benz E350 |
|---|---|---|
| Average best-configuration economy (mpg, UK) | 31 | 31 |
| Average CO₂ (g/km) | 213 | 215 |
| Average estimated annual fuel cost (US EPA) | $3,181 | $3,231 |
| Average passenger volume (cu ft, EPA) | 93 | 98 |
| Model years rated 5★ overall by NHTSA | 8 of 8 | 4 of 6 |
| Average recall campaigns per model year | 4.6 | 0.2 |
| Average owner complaints per model year | 130 | 42 |
| Engine options across these years | 4 | 2 |
Year by Year
| Year | Acura TLX MPG (UK) | NHTSA | Recalls | Complaints | Mercedes-Benz E350 MPG (UK) | NHTSA | Recalls | Complaints |
|---|---|---|---|---|---|---|---|---|
| 2015 | 34 | 5★ | 6 | 342 | 28 | 4★ | 0 | 57 |
| 2016 | 34 | 5★ | 3 | 111 | 28 | 4★ | 0 | 89 |
| 2020 | 32 | 5★ | 5 | 63 | 31 | 5★ | 1 | 24 |
| 2021 | 30 | 5★ | 5 | 102 | 30 | 5★ | 0 | 20 |
| 2022 | 30 | 5★ | 4 | 34 | 31 | 5★ | 0 | 22 |
| 2023 | 30 | 5★ | 4 | 19 | 31 | 5★ | 0 | 24 |
| 2024 | 30 | 5★ | 1 | 5 | 32 | — | 0 | 25 |
| 2025 | 30 | 5★ | 1 | 4 | 34 | — | 2 | 5 |
MPG is each model year's most efficient configuration (US EPA, converted to UK mpg). Recalls and complaints are NHTSA counts as of 6 October 2026; complaints are unverified owner reports and rise with sales volume. See each model's full history: Acura TLX · Mercedes-Benz E350.
Frequently Asked Questions
Which is more fuel-efficient, the Acura TLX or the Mercedes-Benz E350?
Both average about 31 mpg (UK) on their most efficient configurations. Figures are the US EPA combined result converted to UK mpg, averaged over the shared model years; individual engines and years differ, so check the year pages for the exact car.
Which has better NHTSA safety ratings?
The Acura TLX has 8 of 8 model years rated 5★ overall in these years and the Mercedes-Benz E350 has 4 of 6. NHTSA ratings are only comparable between vehicles of similar size and weight, and the test criteria have changed over time.
Which has more recalls and owner complaints?
Per model year, the Acura TLX averages 4.6 recall campaigns and 130 owner complaints; the Mercedes-Benz E350 averages 0.2 and 42. Complaint counts are unverified owner reports and rise with sales volume, so use them as a pointer for what to inspect, not as a reliability ranking.
Where do these comparison figures come from?
Fuel economy, CO₂ and interior volume come from the US EPA's fueleconomy.gov data; ratings, recalls and complaints come from NHTSA. Only model years where both cars have data are compared.
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